Promising New Research For Treating Brain Tumors in Dogs and Humans

by Lori Ennis

Published: October 19th, 2017

promising new research for treating brain tumors in dogs and humans

New research from the Virginia-Maryland College of Veterinary Medicine at Virginia Tech has shown promise for treating brain tumors in dogs, and may one day even be used to help humans!

A study funded by the National Institutes of Health has produced data from clinical trials that show promising results when it comes to treating brain tumors in humans. The study is a collaboration between the College of Veterinary Medicine at Virginia Teach and the Thomas K. Hearn Brain Tumor Research Center at Wake Forest’s School of Medicine.

Currently, the researchers are looking at the safety of a new chemotherapy medicine and delivery methods when treating brain tumors in dogs, as they want to find a safe and effective use of the drug for use in future trials. Dogs and people have similar brains in many aspects, and researchers are optimistic that the data they’ve found and will find will be beneficial for the treatment of tumors in humans as well.

Dr. John Rossmeisl is a professor of neurology and neurosurgery in the Department of Small Animal Clinical Sciences and said that though dogs are benefitting from this, the drug research is a pathway for use in human cancer treatment as well.

A dog in the trial was originally diagnosed with a glioma brain tumor, and gave a survival of only a few months more. She was treated in the trial, which required her to stay at the vet hospital for six days. She had preliminary lab tests and exams done as well as a tumor biopsy. Once the biopsy was processed, she received chemotherapy drugs specially modified for her tumor, and they were delivered directly to her tumor. This chemotherapy drug is unique in that it works by destroying cancerous cells, and not normal brain cells. She went home the next day.

Since March, she’s only been back twice–six weeks after her infusion and four months later for evaluation, exceeding the projected survival rate that was initially given upon diagnosis. More, her tumor has been significantly reduced. Dr. Rossmeisl says that based on the dog’s initial MRI, it appeared to have shrunk approximately 50%, and in the four-month follow-up, it appears as a teeny little spot, compared to what it once was.

She will continue follow-up care every two to three months, and her owners are thrilled she was able to get the treatment she was.

Dr. Rossmeisl said that there are different sub-types of gliomas, so not all dogs will respond the same. Some have lived for a year longer, with their tumor shrinking, while other dogs in the study have seen no difference. That said, this drug in previous generations of development have been used safely in human brain tumor studies and trials and he believes this information will apply to humans as well within the next five years.

The trial began in 2014 and still accepts dogs for participation. They are happy with the positive outcomes they’ve had thus far, and believe there is more to come–for our best friends and for us.

Lori Ennis

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How Much Outdoor Time Does My Dog Need?

Spending time outside is very important for overall physical and mental health, both for humans and animals alike. Our pets, dogs especially, can be quite dependent on the time they spend outdoors. It helps stimulate them, keep them mobile and active, and also helps them spend all that extra energy they have stored which in turn impacts their behavior for the better. But as it is with everything in life, there is always too little and too much of a good thing. So in the end, it does make you wonder – just how much outdoor time does your dog need? And, can you really overdo it? Let’s find out!How Much Outdoor Time Does My Dog Need?The amount of outdoor time your dog needs can vary based on factors such as their breed, age, health, and individual preferences of your dog. It can’t really be the exact same for all dogs out there. Just like humans, some pooches have preferences of their own. Some love to snooze and relax, and aren’t really fans of going outside and zooming about. Others, however, can’t get enough of adventures in the great outdoors. Still, in general, all dogs require at least a small amount of daily outdoor exercise and mental stimulation to stay happy and healthy. With that in mind, these are some main factors that could influence the amount of time your pet needs to spend outside of the house:BreedDifferent breeds have different energy levels and exercise requirements. High-energy breeds like Border Collies or Labrador Retrievers may need more outdoor time compared to lower-energy breeds like Bulldogs or Basset Hounds. As you get to know your pet and the specifics of their breed, this too will become apparent. AgeAge plays a major role in dog energy levels. Puppies generally have more energy and may require several short play and exercise sessions throughout the day. Adult dogs on the other hand usually need at least 30 minutes to 2 hours of exercise per day, depending on the breed and individual needs, whereas seniors usually don’t have as much energy so one walk a day will do just fine for a pooch in his golden years.HealthDogs with certain health issues may have specific exercise restrictions. Consult with your veterinarian to determine an appropriate exercise plan for a dog with health concerns. Don’t overdo it with your dog, if the vet prohibits it. The same goes for seniors, who can’t really play all that much outside. SizeDog size is a big factor in determining energy levels and the need for outdoor fun. Smaller breeds may get sufficient exercise with a shorter walk or playtime, while larger breeds might need longer and more vigorous activities.Individual PreferencesSome dogs are more active and enjoy activities like fetching, running, or hiking, while others may be content with a shorter walk or playtime in the yard. On the other hand, some breeds, due to their inherent traits, might love relaxing outside, even when it's chilly. Others, though, will love the warmth and coziness found indoors. 

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A Six-legged Abandoned Dog Has Surgery to Remove Extra Limbs

A six-legged cocker spaniel found abandoned in a supermarket parking lot in Wales has had surgery to remove her extra limbs. The pooch was named Ariel, after the Little Mermaid, because her extra limbs were fused together, resembling a mermaid’s tail. Greenacres Rescue, a non-profit group from Haverfordwest in Pembrokeshire, Wales, took Ariel in, arranged her surgery, and found her a foster family.  Ariel, who was born with multiple birth defects, was operated on at Langford Vets Small Animal Referral Hospital. Surgeon Aaron Lutchman performed the surgery and managed to save all four limbs amid fears that one hind leg might have to be amputated. “She’s doing really well, she’s bounced back and she’s a happy little dog and we’re hoping she’s going to go on to lead a fabulous little life,” said Lutchman. “She’s got her own little character and even though she’s had a tough start in life she really has done well to come through this as she has… if we can do what we can to help then that’s just absolutely brilliant.” According to Mikey Lawlor, founder and manager of Greenacres Rescue, Ariel was skinny and distressed when she was rescued. “The vet who initially assessed Ariel noted that, in addition to her two surplus back legs, she also had an additional vulva,” said Lawlor. A CT scan later revealed that Ariel was born with only one kidney, which increased the complexity of the medical treatment she required. Unfortunately, the pup’s pelvis never formed properly because she had two hip joints on one side of the body. As a result, Ariel’s normal hind leg had no muscle tone, so there was a chance that that leg had to be amputated as well. “Thankfully, that wasn’t the case though as it’s shown signs of having strengthened a lot in recent months,” Lawlor added.Ariel is recovering nicely after her surgery, having lots of love and fuss from the nursing team. Now that the surgery is behind her, everyone is hoping that she’ll have an easy and quick recovery.“There were two procedures which lasted about two hours, but both went fine. The next day she was up, walking around and eating and drinking.”“Now we just need to keep our fingers crossed she doesn’t get any infections, but she really is in the best of hands,” added Lawlor according to BBC. The brave pooch was discharged over the weekend and has already returned home to her foster family in Wales. According to her vet, Ariel has to rest for the next two weeks to recover completely. The founder of Greenacres Rescue hopes that the organization will be able to find a forever home for Ariel after she completes physiotherapy and recovery. “The response we had to Ariel’s story so far, including calls and emails from as far away as New York and Australia, has been incredible - so I’ve no doubt she’ll be snapped up,” said Lawlor.“I just can’t say enough of a thank you to everyone who’s contributed to helping her.” The organization raised around $19,000 for Ariel’s life-changing surgery thanks to donations from people all over the world.“Ariel was a complicated little dog whose care required close collaboration across a number of our specialist teams, including orthopedics, soft tissue surgery, anesthesia, and radiology,” said Vicki Black, the director of Langford Vets’ Hospital. “As part of the University of Bristol, we are a center committed to career-long learning and are proud to innovate and treat pets like Ariel. We are delighted such a lovely animal has recovered well from her surgery.”Join the PetGuide community. Get the latest pet news and product recommendations by subscribing to our newsletter here.

Do You Need to Clean A Cat's Teeth?

Cats are known and adored for their free spirit, their stubborn nature, their agility, and their cute and cuddly side as well. They are skilled hunters, and as such they have sharp and perfected teeth. But while a cat roaming the outdoors would gnaw and eat prey she previously caught when you have a pet cat, those same teeth are used to eat a very different kind of food. Naturally, this can have a big impact on your cat’s dental health, as the same principles that were true in nature are not applicable for indoor-only cats anymore – which brings up an important question: do you need to clean a cat’s teeth? How important is this for their hygiene? And most importantly, how do you do it? Let’s take a closer look at this question.Do You Need to Clean A Cat's Teeth?Just like for us humans, dental care is important for kitties too. Of course, human and feline teeth are totally different, so dental hygiene is not exactly the same for both. Cat teeth are not brushed as often as our own, but nevertheless, you should provide some level of dental hygiene to your four-legged friend, as it can be a great benefit for their health. Neglect their little chompers for a long time, and their teeth could deteriorate over the years. This can lead to great discomfort, pain, loss of appetite, and from there – many other problems as well. So, in short, keeping your cat’s teeth clean and maintained is an essential aspect of caring for them. Of course, regular vet checkups will give you a good insight into their dental health and will allow you to spot problems early on and tackle them more easily. But it also goes a long way to know the tips and tricks that help maintain a cat’s dental hygiene. Here are just a few:Regular Brushing

Are Bengal Cats Really That Wild? Here's What Science Has to Say.

Bengal cats are a truly stunning feline breed, in many ways. According to the International Cat Association (TICA), they hold the title of being the most popular cat breed globally, and it doesn’t really come as a surprise. Their unique and exotic appearance, their unavoidable charm, and their slender physique are certainly the reason for this prestigious title. But even though they are popular, Bengal cats are a relatively new breed in the field of domesticated cats. While most ordinary domestic cat breeds have been around for thousands of years, Bengal cats have been around for less than a century, which comes as a stark contrast. They are a hybrid breed as well, having been created in the 1960s. They came about from the crossing of the domestic cat (Felis Catus), and the Asian Leopard cats (Prionailurus Bengalensis), which are a small, spotted, wild cat species living in Asia. What makes the combination unique is the fact that these two cat species had a common ancestor about 6 million years ago, which means that the genetic differences between them are incredible. The differences are even greater than between humans and chimpanzees!The resulting breed is the Bengal cat, and it is adored for its exotic appearance. It has special spots, just like ocelots or leopards. But most folks ascribe the unique coloration and patterns of these felines to the DNA they received from their wild and distantly related ancestors. And that’s why scientific folks paid special attention to the ancestry of Bengal cats. Greg Barsh, MD, Ph.D., Faculty Investigator at HudsonAlpha Institute for Biotechnology and Professor of Genetics at Stanford University,  himself an expert in the genetics of feline coat coloration and patterning is a key figure in the research process of Bengal ancestry. Together with his team, which is led by Chris Kaelin, Ph.D., and Kelly McGowan, MD, Ph.D., Mr. Barsh is working hard towards unraveling Bengal ancestry through the genetics of popular color traits."Cats are wonderful companions," he explains for  Phys.org, "but our interests go beyond their beautiful and exotic appearance. Like the amazing variation among different dog breeds, artificial selection can be a very powerful engine to create morphologic diversity. What's different about Bengal cats from dogs is the raw genetic material–dogs trace their heritage to wolves from tens of thousands of years ago.""In contrast, Bengal cats trace their heritage to completely different species from millions of years ago. Understanding how these distantly related genomes interact is a general question that applies to any situation when different species exchange genes, from crops to aquaculture to humans and Neandertals."And even though this is a relatively new breed, started about 60 years ago by a few cat enthusiasts, it has grown incredibly during this time. Today, there are hundreds of thousands of registered Bengal cats, which are produced by about 2,000 breeders. Chris Kaelin, the leader of the Bengal cat DNA study, said “Cat fanciers and breeders are very interested in the research, in part because they want to know more about the science behind artificial selection, and in part, because they want to know if our results can help them produce cats with rosettes, stripes, or other exotic markings.” He also added "This is a great example of citizen science–our work has been enabled by the willingness of breeders to participate, and we share our results with the community."One of the surprising discoveries that was produced from the study is that Asian Leopard DNA contributes no more than a few percent to the overall Bengal Cat DNA. In fact, it is revealed that there isn’t one or even a few Asian leopard genes that are causing the unique spotted Bengal appearance. "One of the original motivations for bringing together DNA from the two species was to select for Asian leopard DNA that would recapitulate the appearance of an exotic wild cat in a companion animal," said Kaelin. "It turns out that some of the most striking examples of selection in the breed are for traits that were already present, but very rare, in domestic cats."So, the study reveals that the Bengals are in many ways totally unique. Mixing the two very unique breeds resulted in a cat that is exotic, elegant, charming, and above all loveable. And now, the results published are providing valuable information to all the enthusiasts in love with the Bengal breed. 

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