Drug That Could Extend Lifespan of Senior Dogs Enters Clinical Trial

by Angela Vuckovic

Published: February 6th, 2024

Holly Michele/Shutterstock

A new and revolutionary drug that could possibly extend the lifespan of healthy, senior dogs, is now entering a major clinical trial. It also has a first patient - an 11-year-old Whippet named Boo. Going by the codename LOY-002, this drug is designed to provide a few more years to senior dogs of most sizes. It is the product of a startup biotech company called Loyal and is the fruit of their hard work and arduous research.

Celine Halioua, the founder and CEO of Loyal, said that the company is working hard to develop several products aimed at the longevity of dogs. One of their initial projects, the LOY-001, was a drug aimed to extend the lifespan of giant and large dog breeds. In November of 2023, this project received the support of the FDA, paving the way for the company's further successes.

The underlying mechanisms of aging were the first focus of the company as it developed LOY-001. The drug works by reducing IGF-1, an insulin-like growth factor that is a key biomarker hormone that drives cell growth. It is believed that this reduced the lifespan of extra-large dogs. Similarly, the LOY-002 project aims to extend the lifespan of normal-sized dogs, by improving their metabolic health and thus delaying the onset and the impact of diseases that come with old age.

“LOY-002 is a slightly different mechanism [than LOY-001] for senior lifespan extension. It’s a little bit more of a reversal mechanism. It’s not going to make a 10-year-old dog a puppy, but we’ve seen a rescuing in age-related functional decline in dogs that have been treated with this drug,” said Halioua in an interview with dvm360.

The newest study for LOY-002 is expected to last 4 years, and include one thousand enrolled dogs. “It will be one of the largest veterinary clinical studies that, as far as we know, has ever been run,” added Halioua.

The first ever receiver of the drug, Boo, was enrolled into the program in Harrisburg, Pennsylvania, at the Animal Hospital of Dauphin County. There, an associate veterinary and STAY study investigator, Coby Rudakewiz, became a part of the program for the first time, witnessing its incredible potential. “I’m genuinely excited to be able to share what we’ve seen as a life-changing product to dogs of all sizes,” he said.“This is what it’s all about - keeping dogs feeling their best to enjoy a long life with their owners who love them.”

“The launch of this study brings us one step closer to helping senior dogs have more, healthier years with their families…The scale and complexity of STAY reflect Loyal’s commitment to creating demonstrably effective and safe products,” Halioua added. “This is a massive undertaking that wouldn’t be possible without the partnership of the many veterinarians and technicians operating the study in their clinics, and the participating dogs and owners helping advance therapies for all dogs.”

For the time being, the company is working hard to receive conditional approval for its revolutionary drug. This would allow them to begin offering it through veterinarians as soon as 2025. This could mean a world of difference for many senior doggos and their families. Seeing your senior doggo enjoy a few extra years without the issues common to old age is nothing short of true happiness, and would mean that the company’s hard efforts were not in vain.

Ultimately, this innovative drug gives us hope for the future and makes us wonder what other ground-breaking drugs could we see in the years ahead.

Angela Vuckovic

A proud mama to seven dogs and ten cats, Angela spends her days writing for her fellow pet parents and pampering her furballs, all of whom are rescues. When she's not gushing over her adorable cats or playing with her dogs, she can be found curled up with a good fantasy book.

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Perhaps you spotted tears streaming from your pet’s eyes and wondered: do dogs cry tears as an emotional response? Or is there a different explanation for this phenomenon? Well, the answer is pretty straightforward – dogs don’t produce tears because of their emotions like we humans do. They produce tears primarily to lubricate their eyes, and remove dust and other irritants. But, this does not mean that they don’t express emotions in other ways – here’s what you need to know about your teary-eyed furball.Do Dogs Cry Real Tears?If you spot tears running from your dog’s eyes, you are not deceived – they are real. However, they are not tears of sadness or emotion, as dogs simply don’t express feelings the same way as we do. The role of those tears is more of a bodily function. They are there to lubricate the eye, making sure it functions as it should. After all, dogs can just rub their eyes or place a few drops inside when needed. So, their body does the job for them, and hence the tears. Of course, an excessive amount of tears is not natural. And neither are dry and tearless eyes. So, in either one of these cases, you should schedule a visit with your vet. Dry eyes in dogs are also known as keratoconjunctivitis sicca (KCS) or "dry eye syndrome," and can lead to discomfort, irritation, and potential complications if left untreated. In many cases of dry eyes, veterinarians prescribe artificial tears or  lubricating eye drops to help moisturize the eyes and relieve discomfort. These drops can help supplement the natural tear production and provide relief from dryness. 

After 5 Long Years, a Lost Senior Dog is Reunited With His Owner

It seems that year is off to a good start in Sharonville, Ohio, where a true miracle happened for a hopeful pawrent. A Butler County woman named Hannah experienced immense relief and happiness after she was reunited with her long-lost doggo, at the annual My Furry Valentine adoption event in Sharonville. Will, Hannah’s wonderful Golden Retriever buddy had been missing for five years, after he wandered away from home in October 2019. Devastated, Hannah and her family searched for days and weeks for Will, but without success. In the end, fearing the worst, they had to let go of their wavering hopes.But incredibly, much to their amazement, their hopes were rekindled. They spotted a stray dog photo posted out of Clermont County – the resemblance to Will was uncanny. Hannah quickly sent a Facebook message to the nonprofit Clear the Clermont County Animal Shelter, inquiring about the dog - apparently named Rome. After a brief explanation, she said she believed it was none other than her beloved Will. 

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New Study Reveals Dogs Can Sniff Out Neurodegenerative Diseases

We all know that doggos have incredible noses and a superb sense of smell. It is tens of thousands of times stronger than our own. This makes us wonder – what secrets can such a sense of smell unveil? Many scientists consider the canine sense of smell a great potential to enhance human lives thanks to its accuracy. And that is exactly what was unveiled in a recent study published in “bioRxiv”, by researchers Samuel V. Johnston and Lisa Holt from Cold Spring Harbor Laboratory. Thanks to their efforts, and the incredible abilities of doggos, it was revealed that our four-legged friends have the potential to detect neurodegenerative diseases, such as Parkinson’s. Parkinson’s disease is a terrible condition, affecting primarily seniors. What is even worse is that this disease has many difficulties in diagnosis, which prevents doctors from accurately identifying the disease in the early stages. But the breakthrough study could change all that! Thanks to doggos and their powerful noses, we could be on the brink of completely changing the way Parkinson’s is diagnosed. “Dogs have an extraordinary olfactory capability, which far exceeds that of humans. Dogs’ sense of smell seems to be the main sense, allowing them to not only gather both current and historical information about their surrounding environment, but also to find the source of the smell, which is crucial for locating food, danger, or partners for reproduction.”  writes Agata Kusiak, from the Institute of Animal Sciences, Warsaw University. “Dogs can be trained by humans to use their olfactory abilities in a variety of fields, with a detection limit often much lower than that of sophisticated laboratory instruments.”Utilizing this remarkable sense of smell, scientists trained 23 dogs of different breeds and backgrounds, to successfully differentiate between samples of both Parkinson’s-positive individuals and Parkinson’s-negative individuals. The results were more than successful, with the dogs showcasing 86% sensitivity and 89% specificity in distinguishing the samples. In many ways, this is a revolutionary study and opens new doors and new possibilities in medical diagnostics. What is even better, it offers new hope for the timely detection of Parkinson’s disease. However, it is important to note that the study is still in relative infancy, and is still awaiting peer review. But the potential here is incredible. If validated, the study could help improve patient outcomes, and help with early diagnosis of this troubling disease.

A Pennsylvania Dog Shocked Its Owners After Eating $4000 in Cash

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A Small Cat Family Was Found Living in the Ceiling of a Restaurant

Cats choose their homes in the unlikeliest of places! And a recent event from Massachusetts, when a momma cat and her four newborn kittens were discovered living in the ceiling of a New Bedford restaurant, definitely confirms this.The  Animal Rescue League of Boston said that they received a call from the employees of a local New Bedford restaurant. It was no ordinary call, however, as the employees said that they were “hearing kittens meowing from the ceiling”. The momma cat, however, was no stranger at the premises. The staff noticed her around the place before but did not suspect that she was pregnant – or that she was living in the ceiling. But hearing the distinct sound of kittens meowing, the employees were quick to understand what happened. The animal rescue team quickly responded to the call, and their field service agents soon spotted the tiny kittens through a small slit between the restaurant wall and a hole in the ceiling. With a little bit of patience and work, the rescue team managed to retrieve all four kittens from the ceiling space, and safely transport them to the rescue shelter. Rescuing the momma cat, however, was not as easy. Cunning and careful, the cat evaded all the efforts of the team, including artificial kitten sounds, and tasty cat food. Ultimately, the team employed a humane cat trap that they placed within the ceiling. The next day, they reported that the momma cat entered the trap at around 11 p.m. at night, which allowed them to reunite her with her children at the Animal Rescue League's Boston Animal Care and Adoption Center. There, they were all treated and given veterinary care."Community cats are incredibly resilient, and have a knack to find shelter for themselves and their offspring," the animal rescue league said in a subsequent statement for  NBC Boston. "However, kittens born this time of year are incredibly vulnerable to the elements and other potential dangers and ARL urges the public that if a cat with offspring are discovered, to contact ARL Field Services for assistance." In the meantime, the happy momma cat and her babies are resting and growing, until the time comes when they can be put up for adoption and find forever homes and each their own happy ending to this unusual story.

New Survey Ranks America's Top Dog Breeds by State

There’s no doubt about it - Americans love their dogs! We know that your pooch is the best breed, but have you wondered which are the most favored dog breeds in America? Forbes surveyed 10,000 dog owners across the 50 states to find America’s top dog breed. The survey involved the top 25 most popular dog breeds nationwide, according to the American Kennel Club. So, what is America’s top dog? As it turns out, “no breed in particular” is the country’s favorite at 13%.However, if Americans had to decide, they’d pick the Australian shepherd as a favorite, followed by the German shepherd and the bulldog.The highly intelligent and energetic Australian shepherd was ranked as the top dog breed in 10 states, including Alabama, Arizona, Alaska, Arkansas, Georgia, Indiana, Montana, Missouri, New York, and Virginia. This breed was also voted the second favorite in nine states. Although Aussies won the popularity vote, the German shepherd was the number one pick in 16 states. That’s more than any other breed!Known for its loyal and courageous nature, the German shepherd is the most common breed to serve as a police K9 but also makes a wonderful family companion. They ranked as the second favorite dog breed in nine states. Interestingly, more men than women picked German shepherds as their favorite breed (9% compared to 6%). America’s 3rd favorite breed, according to Forbes, is the bulldog. The English bulldog is a medium-sized dog breed, best known for its stocky build, large head, and wrinkled face. The bulldog ranked as the top dog in eight states, including Illinois, Connecticut, Missouri, Mississippi, North Carolina, South Carolina, West Virginia, and Utah. Among all states, Nebraska ranked the bulldog lowest, placing this breed at 24th place, The lovable and friendly Labrador retriever ranked as the nation’s 4th favorite breed. Thanks to their affectionate, friendly, and energetic nature, Labs make great companions to people of all ages and families with children. Labrador retrievers ranked as the most favorite dog breed in 10 states, including Louisiana, Idaho, Minnesota, Montana, Massachusetts, Nebraska, New Hampshire, Oregon, South Dakota, and West Virginia. Bernese mountain dog is the 5th favorite dog breed in the United States. Large in size and built for hard work, Bernese mountain dogs are easy to train and make affectionate, loyal, and faithful companions. So, it’s no surprise that this doggo ranked as the most favorite breed in nine states. Compared to four other top-ranked breeds, the Bernese mountain dog had the most varying results, with 10 states ranking this breed in the bottom 10.The beagle is the nation’s favorite small breed. Ranked as the 6th favorite breed overall, the beagle was placed in the top 10 favorite breeds in all but seven states. This breed received the lowest ranking in Utah, where it was voted as the state’s 3rd least favorite breed.The golden retriever comes in at 7th place, after being voted as the most favorite dog breed in Michigan and Wisconsin. Medium in size and best known for their gorgeous golden coats, golden retrievers are loving, loyal, and affectionate companions to active people and families with children. Goldens were the 2nd favorite dog breed in four states, including New Hampshire, North Dakota, Connecticut, and Vermont. This breed ranked the lowest in Alabama, where it received 17th place.These are America’s most favorite dog breeds, but the nation also has the least favorite doggo. This title goes to the Havanese, which was the bottom-ranked breed in 33 states.The Havanese is followed by Pembroke Welsh Corgi which was the least favorite dog breed in 17 states. And what about you? What’s your favorite and least favorite dog breed?Join the PetGuide community. Get the latest pet news and product recommendations by subscribing to our newsletter here.

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